Setting a new standard
for treating autoimmune disease
Zag Bio’s therapies harness the natural processes of the immune system by targeting the thymus to generate long-lasting and beneficial immune cells that deliver a localized protective effect. This approach has the potential to restore immune balance in millions of people impacted by autoimmune disease.
The thymus is the source of a balanced immune system, also known as central tolerance.
The thymus trains developing immune cells to differentiate between ‘self’ and ‘non-self’, creating conventional T cells that destroy harmful invaders, and regulatory T cells that protect the body’s own tissues. Autoimmune diseases occur when the immune system falls out of balance. In this case, autoreactive conventional T cells lose their earlier training to avoid ‘self’ antigens, and they attack and potentially destroy a person’s own cells and tissue.
Zag Bio seeks to treat autoimmune disease by engaging the body’s natural process to restore balance to the immune system.
Zag’s therapy delivers new instructions.
Our bifunctional antibodies deliver selected antigens to specialized antigen-presenting cells in the thymus, where they encounter immune cells.
Innovating with Our Platform
Immune cells learn tolerance.
Developing immune cells are trained to recognize the antigens delivered by Zag’s therapy, generating antigen-specific regulatory T cells designed to protect against autoimmune attack.
Leveraging Science of the Thymus
Immune tolerance is restored at the site of disease.
Once trained, antigen-specific regulatory T cells leave the thymus and travel to tissues that express the antigen and are under attack. Once there, the regulatory T cells suppress the autoimmune response, restoring immune tolerance and promoting healing.
Advancing Our Pipeline
We are taking a bold new direction for treating autoimmune disease, motivated by a shared commitment to deliver more effective and durable therapies for people impacted by autoimmune disease.
We are intentionally navigating in new territory, energized by the potential that targeted and durable therapies can bring to the millions of people living with autoimmune disease today.
See What’s Zagging
